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The need for new and better
antidepressants: reboxetine a new option
Dencker SJ
Neuropsychiatry Unit,
Institute of Clinical Neurosciences,
Sahlgrenska University Hospital, Goteborg, Sweden.
Acta Psychiatr Scand Suppl 2000; 402:6-11
ABSTRACT
The selective serotonin reuptake inhibitors (SSRIs)
have obtained global attention but have not demonstrated superior efficacy
in major depression compared with older tricyclic antidepressants.
From a pharmacological viewpoint the noradrenergic system in the brain
appears to have a central role in neurotransmitter organization. The
importance of noradrenaline in depression is supported by its association
with clinical parameters such as vigilance and drive. Reboxetine is a
selective noradrenaline reuptake inhibitor--the first in its class to be
marketed. In both preclinical and clinical studies reboxetine has been
found to be an effective and safe antidepressant. Furthermore,
reboxetine restores a patients' social functioning producing a better
quality of remission than fluoxetine.
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Reboxetine research /
abstracts
1. Reboxetine
role in antidepressant therapy
2. Reboxetine
efficacy and tolerability
3. Reboxetine
clinical pharmacologic profile
4. Reboxetine
Inhibiting noradrenaline
and serotonin reuptake
5. Reboxetine
and depression in the elderly
6. Reboxetine
with severe major depressive disorder
7. Reboxetine
clinical efficacy in major depression
8. Reboxetine
tolerability and safety for major depression
9. Reboxetine
comparison with fluoxetine
10. Reboxetine
versus fluoxetine, impact on social functioning
11. Reboxetine versus
fluoxetine, differential effects
12. Reboxetine
prevents relapse in major depression
13. Reboxetine
efficacy compared with imipramine
14. Noradrenaline
reuptake inhibition
15. Antidepressants
noradrenergic versus serotonergic
16. Reboxetine
in the treatment of bulimia
17. Reboxetine
hemodynamic effects in healthy males
18. Reboxetine
effects of antidepressant therapy
19. Reboxetine
place in antidepressant therapy
20. Reboxetine
stimulant effects in patients with narcolepsy
21. Reboxetine
selective noradrenaline reuptake inhibitor (NARI)
Reboxetine
manufacturer's product insert

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